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Iritis


Iritis

Iritis is a form of anterior uveitis and refers to the inflammation of the iris of the eye.
Signs and symptoms
Ocular and periorbital pain
Photophobia
Consensual photophobia (pain in affected eye when light is shone in unaffected eye)
Blurred or cloudy vision
White blood cells (leukocytes) (resulting in a grey or near-white haze) and protein (resulting in tiny white dots) in the anterior chamber, often called "cells and flare."
Synechia or adhesion of iris to lens or cornea

Causes
People with ankylosing spondylitis and other HLA-B27 related disorders are prone to iritis, iridocyclitis, and other forms of uveal tract inflammation. Iritis is also found in those with rheumatoid arthritis, Behcet's disease, Crohn's disease, lupus, Reiter's disease, chronic psoriasis, psoriatic arthritis, sarcoidosis, scleroderma, and ulcerative colitis. Iritis is usually secondary to some other systemic condition, but can be the only apparent somatic symptom.

Complications
Cataract, glaucoma, corneal calcification, posterior uveitis, blindness

Treatment
Steroid anti-inflammatory eye drops (such as prednisolone acetate)
Dilating eye drops (to help prevent synechia and reduce photophobia)
Pressure-reducing eye drops (such as brimonidine tartrate)
Oral steroids (such as prednisone)
Subconjunctival steroid injections
Steroid-sparing agents such as methotrexate (for prolonged, chronic iritis
)

References

Care of the Patient with Anterior Uveitis (CPG7
http://www.aoanet.org/clincare/pdf/CPG-7.pdf
Iritis Organization
http://www.iritis.org/
http://eyelearn.med.utoronto.ca/Lectures04-05/RedEye/14Iritis.htm#focus


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