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الالية المرضية لالتهاب البنكرياس الوراثي


الالية المرضية لالتهاب البنكرياس الوراثي

المرجع: 
Whitcomb DC. Genetic aspects of pancreatitis. Annu Rev Med 2010
الالية المرضية لالتهاب البنكرياس الوراثي

يبين الشكل الية عمل الطفرات الجينية المسببة لالتهاب البنكرياس الوراثي Genetic حيث يظهر العمل الطبيعي للجينة ويشرح الطفرة التي تسبب خللها وبالتالي التهاب البنكرياس.

Ghufran's picture
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One large, international study showed that hereditary pancreatitis patients have a 54-fold higher risk of PC than the general population; those patients who smoke cigarettes increase this cancer risk to 154-fold
mbs2380's picture
mbs2380
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I notice in the books that they mean PRSS1 gene mutation by the term herditary pancreatitis, and though the study u mention was on them. Anyway, the risk of Pancreatic Ca is still high in patients with chronic pancreatitis of any cause.
the problem is with no consensus found an effective way of screening them. some suggest CA19-9, CT, EUS...

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Ghufran
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Quote:
I notice in the books that they mean PRSS1 gene mutation by the term herditary pancreatitis, and though the study u mention was on them

Yes they do.

Quote:
the problem is with no consensus found an effective way of screening them. some suggest CA19-9, CT, EUS...

In addition, in one of the studies (in the Michigen university) they found that "‘doing nothing’ strategy actually provided the greatest quantity of remaining years of life, the greatest remaining quality-adjusted life years, and the lowest cost"

Attached is a lil power point presentation that I gave to GI folks in Emory University hospital.

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mbs2380
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the file didn't open with me

Ghufran's picture
Ghufran
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Attached is a rar file contains the presentation with office versions

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mbs2380
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Thanks. god job!
best luck

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Ghufran
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Thanks to you for keeping us updated.

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mbs2380
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