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Help! Systematic Review: Hydroxyurea for the Treatment of Sickle Cell Disease


Help! Systematic Review: Hydroxyurea for the Treatment of Sickle Cell Disease

السلام عليكم
I have to read this 300 page systematic review entitled: Hydroxyurea for the Treatment of Sickle Cell Disease
I have a few questions already, perhaps you can help me! Rolling Eyes

(إن الله لا يغير ما بقوم حتى يغيروا ما بأنفسهم)

www.goodreads.com
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Angel Anas's picture
by
السنة الثالثة

neutropenia?
neoplasm?
homozygosity?

I'm not sure what those are, I would be thankful if you'ld translate them Rolling Eyes

Angel Anas's picture
Angel Anas
السنة الثالثة

1. What is the efficacy (results from controlled clinical studies) of hydroxyurea treatment
for patients who have sickle cell disease?
2. What is the effectiveness (in everyday practice) of hydroxyurea treatment for patients
who have sickle cell disease?

Aren't both the same thing? I mean efficacy=effectiveness, right?!

Angel Anas's picture
Angel Anas
السنة الثالثة


Hemoglobin is 3 types?
HB A which is the normal adult hemoglobin
HB S which is the causing factor of the sickle disease
HB F Fetal hemoglobin which almost completely disappear a few months after birth?

Is this right? or did my memory fail me! Laughing out loud
It says Hydroxyurea increases HB F hemoglobin! and not HB A

Angel Anas's picture
Angel Anas
السنة الثالثة

Sickle cell anemia refers specifically to the condition associated with homozygosity for the Hb S mutation (Hb SS).
I didn't get the whole sentence Rolling Eyes
Angel Anas's picture
Angel Anas
السنة الثالثة

vaso-occlusive crises
acute chest syndrome
Angel Anas's picture
Angel Anas
السنة الثالثة

a broad range of study designs: 1) studies that tested an intervention
aimed at overcoming barriers to accessing scheduled care, receiving medication prescriptions, or
adhering to medications; 2) studies in which patients or providers or family members described
what they perceived to be barriers to accessing scheduled care, receiving medication
prescriptions, or adhering to medications; and 3) studies that tested whether supposed barriers
were actually associated with accessing scheduled care, receiving medication prescriptions, or
adhering to medications
can anyone please tell me what "accessing scheduled care" means here Evil
Angel Anas's picture
Angel Anas
السنة الثالثة


thrombocythemia?
thrombo=خثرة
cythemia ---> ارتفاع الخلايا في الدم؟
يعني خثرة بسبب ارتفاع الخلايا (المنجلية غالباً) في الدم؟
في هيك شي؟! Rolling Eyes

Angel Anas's picture
Angel Anas
السنة الثالثة

It is written that:
All searches were limited to English-language articles involving treatment of humans.
If I remember correctly from the Fabulous EBM course Cool , not using articles of all languages significantly decreases the reliability and strength of the Systematic Reviews!
It's from John-Hopkins , they' usually make strong research as far as I know
but I guess it's very very hard to translate every article....
Angel Anas's picture
Angel Anas
السنة الثالثة


retrospective;

Angel Anas's picture
Angel Anas
السنة الثالثة


التعليق الخير كان بالخطأ Embarrased
-------------------------------
حدا يساعدني إذا سمحتم Rolling Eyes

Angel Anas's picture
Angel Anas
السنة الثالثة


لك يا حزين .... كأنو هي المناقشة إلك لحالك Laughing out loud

Ji-B-M's picture
Ji-B-M
مدرس


Laughing out loud

Quote:
Although I was astonished to read that there's actually a systematic review that's 300 pages !!!! Shocked

Well actually, it's 298 pages. Research teaches you to be acurate. Cool

Quote:
(Are you sure it's a systematic review?!)

Well it has this on the top:
Evidence Report/Technology Assessment
I also understood it's a "government report"
but I was told it is a Systematic Review Rolling Eyes

Quote:
Why do you have to read it in the first place? I mean for what purpose?

I told you earlier that I planned to go to Mayo Clinic for research.
Well guess what, I'm sitting right here, right now in Mayo Clinic, Rochester MN, reading this review Eye-wink
I'm going to be working on a project independent on this report as it seems!

Quote:
As for your questions, almost all of them can be easily answered by looking them up in a dictionary

I don't have any medical dictionaries with me Embarrased
I was able to find a lot of info by myself, but I couldn't find everything Rolling Eyes

Can you put the links to the online medical dictionaries? Rolling Eyes

Quote:
I think some questions, however, might be hard to find answers for online (I mean specific answers), I think that's where we can scrub in and help out..

We can try to help you answer those kind of questions inshaAllah..

Thanks Very Happy

Angel Anas's picture
Angel Anas
السنة الثالثة


تماثل اللواقح= homozygosity
صارت العبارة مفهومة؟

never_give_up's picture
never_give_up
بعد التخرج


yup Eye-wink
thanks

Angel Anas's picture
Angel Anas
السنة الثالثة

thanks man! Very Happy

But can you put the links to the medical dictionaries please. Rolling Eyes

Angel Anas's picture
Angel Anas
السنة الثالثة


شوفولي هي شو ظريفة:

Quote:
MEDLINE
Search String Returns
(“Anemia, Sickle Cell”[MeSH] OR “sickle cell”[tiab]) AND (“Hydroxyurea”[MeSH] OR hydroxyurea[tiab]
OR hydrea[tiab] OR hydroxycarbamide[tiab]) AND English[lang] NOT (animal[mh] NOT human[mh])
NOT review[pt] NOT “meta-analysis”[pt]
(“Hydroxyurea”[MeSH] OR hydroxyurea[tiab] OR hydrea[tiab] OR hydroxycarbamide[tiab]) AND ("Drug
Toxicity"[MeSH] OR "drug toxicity"[tiab] OR toxicity[tiab] OR harm[tiab] OR "adverse event"[tiab] OR
neoplasms[mh] OR neoplasm*[tiab] OR malignancy[tiab] OR cancer[tiab] OR "Leg Ulcer"[MeSH] OR
"leg ulcer"[tiab] OR "Nausea"[MeSH] OR nausea[tiab] OR vomit*[tiab] OR "Alopecia"[MeSH] OR "hair
loss"[tiab] OR myelosuppression[tiab] OR (delay[tiab] AND (development*[tiab] OR growth[tiab])) OR
teratogen*[tiab] OR "Safety"[MeSH] OR safety[tiab] OR "Leukemia"[MeSH] OR leukemia[tiab]) AND
English[lang] NOT (animal[mh] NOT human[mh]) NOT review[pt] NOT “meta-analysis”[pt]
("Anemia, Sickle Cell"[MeSH] OR "sickle cell"[tiab]) AND ("Hydroxyurea"[MeSH] OR hydroxyurea[tiab]
OR hydrea[tiab] OR hydroxycarbamide[tiab] OR "Phenylbutyrates"[MeSH] OR "sodium
phenylbutyrate"[tiab] OR arginine[mh] OR butyrate[mh] OR "arginine butyrate"[tiab] OR
"decitabine"[Substance Name] OR decitabine[tiab] OR "Azacitidine"[MeSH] OR azacitidine[tiab] OR
azacytidine[tiab] OR "5-azacitidine"[tiab] OR "5-azacytidine"[tiab] OR "Penicillins"[MeSH] OR
penicillin[tiab] OR "Folic Acid"[MeSH] OR "folic acid"[tiab] OR folate[tiab] OR "Vaccines"[MeSH] OR
"Vaccination"[MeSH] OR vaccine*[tiab] OR "iron chelation"[tiab] OR (("Iron"[MeSH] OR iron[tiab] or
Fe[tiab]) AND ("Chelation Therapy"[MeSH] OR "Therapeutics"[MeSH] OR "chelation therapy"[tiab]))
OR "Nutrition Therapy"[MeSH] OR "nutrition therapy"[tiab] OR "nutrition counseling"[tiab] OR
("Pain"[MeSH] AND management[tiab]) OR "pain management"[tiab] OR "Dental Care for Chronically
Ill"[MeSH] OR "chronic transfusion"[tiab] OR (chronic[tiab] AND transfusion[tiab]) OR "Bone Marrow
Transplantation"[MeSH] OR "bone marrow transplant*"[tiab] OR treatment[tiab] OR "Patient Care
Management"[MeSH] OR "case management"[tiab]) AND ("Health Policy"[MeSH] OR "Ethics"[MeSH]
OR ethic*[tiab] OR "Delivery of Health Care"[MeSH] OR "delivery of health care"[tiab] OR "health care
delivery"[tiab] OR "Social Support"[MeSH] OR "Psychology"[MeSH] OR psychology[tiab] OR bias[tiab]
OR "Psychology"[MeSH] OR "Costs and Cost Analysis"[MeSH] OR cost[tiab] OR "Health
behavior"[MeSH] OR communication[tiab] OR Barrier*[tiab] OR "patient satisfaction"[tiab] OR
"Comorbidity"[MeSH] OR comorbidity[tiab] OR "Depression"[MeSH] OR depression[tiab] OR
"socioeconomic status"[tiab] OR "Social Support"[MeSH Major Topic] OR "family support"[tiab] OR
"Education"[MeSH] OR education[tiab] OR "Insurance, Health, Reimbursement"[MeSH] OR "Quality of
Health Care"[MeSH] OR "quality of care"[tiab] OR "practice pattern"[tiab] OR "disease severity"[tiab]
OR burden[tiab] OR "cognitive ability"[tiab] OR respect[tiab]) AND English[lang] NOT (animal[mh] NOT
human[mh]) NOT review[pt] NOT “meta-analysis”[pt]
(“Anemia, Sickle Cell”[MeSH] OR “sickle cell”[tiab] OR "Thrombocythemia, Hemorrhagic"[MeSH] OR
“essential thrombocythemia”[tiab]) AND (“Hydroxyurea”[MeSH] OR hydroxyurea[tiab] OR hydrea[tiab]
OR hydroxycarbamide[tiab]) AND English[lang] NOT (animal[mh] NOT human[mh]) NOT review[pt]
NOT “meta-analysis”[pt]
("Anemia, Sickle Cell"[MeSH] OR "sickle cell"[tiab]) AND ("Health Policy"[MeSH] OR "Ethics"[MeSH]
OR ethic*[tiab] OR "Delivery of Health Care"[MeSH] OR "delivery of health care"[tiab] OR "health care
delivery"[tiab] OR "Social Support"[MeSH] OR "Psychology"[MeSH] OR psychology[tiab] OR bias[tiab]
OR "Psychology"[MeSH] OR "Costs and Cost Analysis"[MeSH] OR cost[tiab] OR "Health
behavior"[MeSH] OR communication[tiab] OR Barrier*[tiab] OR "patient satisfaction"[tiab] OR
"Depression"[MeSH] OR depression[tiab] OR "socioeconomic status"[tiab] OR "Social Support"[MeSH
Major Topic] OR "family support"[tiab] OR "Education"[MeSH] OR education[tiab] OR "Insurance,
Health, Reimbursement"[MeSH] OR "Quality of Health Care"[MeSH] OR "quality of care"[tiab] OR
"practice pattern"[tiab] OR burden[tiab] OR respect[tiab] OR religion[MeSH] OR spirituality[tiab] OR
religion[tiab] OR “internal-external control”[MeSH]) AND English[lang] NOT (animal[mh] NOT
human[mh]) NOT review[pt] NOT “meta-analysis”[pt

]

Angel Anas's picture
Angel Anas
السنة الثالثة

Quote:
Search String Returns

ما في Returns
هي عبارة عن الــ Search String لهذا الــ review على الـ MEDLINE
خفيفة وظريفة ما Cool
خرج تحطوها كمثال بأحد محاضرات الـ EBM Twisted Evil

Angel Anas's picture
Angel Anas
السنة الثالثة
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