تصفح
دخول
تسجيل
نسيتها؟

Apple Stem Cells Offer Hope For Aging and Damaged Skin


Apple Stem Cells Offer Hope For Aging and Damaged Skin

http://www.lef.org/magazine/mag2008/nov2008_Apple-Stem-Cells-Offer-Hope-for-Aging-Damaged-Skin_01.htm

As we age, the reduced turnover of our cells means we can lose control over how our skin ages. Epidermal stem cells needed to create healthy new skin are significantly reduced and function less efficiently. A discovery based on promising plant stem cell research may allow you to regain control.

Scientists have found that a novel extract derived from the stem cells of a rare apple tree cultivated for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance.

Planting a Seed of Hope
Plants also have stem cells. Like humans, plant stem cells depend on epigenetic control and signals from surrounding cells for their development. Unlike humans, however, each plant-derived adult stem cell possesses the ability to generate a whole new plant. Scientists have found a way to harness the power of plant stem cells by growing plant tissues in culture.

The technique is a relatively simple one. First, viable tissue is obtained from a source plant. This material is called an explant. Next, a small cut is made in the explant. New cells form on the surface of this cut in an attempt to heal the wound. This colorless mass of cells is called a callus. The slowly dividing cells of a callus are undifferentiated cells that lack the characteristics of normal plant cells. They are essentially unprogrammed and full of potential.

With this technology, it is theoretically possible to propagate any plant cell in a liquid culture, opening up a whole new realm of possibilities. This fact started scientists thinking—what would happen if an extract of genetically long-lived plant stem cell tissue was applied to human skin?

Comparing Apples to Apples
Today, apples are cultivated primarily to enhance their appearance and flavor. But before the rise of refrigeration, an apple’s ability to stay fresh for a long time was its most sought-after characteristic.

For this reason, a special variety of apple was cultivated in the middle of the 18th century that could be stored for a greatly extended period of time. In essence, it was the genetically modified, longer-living stem cells of this tannin-rich variety of apple, called the Uttwiler Spätlauber apple, which were responsible for its unique storage longevity.

In a certain isolated area of rural Switzerland, a few of these hardy apple trees still survive today. Scientists obtained an explant from the leaf of one of these trees to produce a special anti-aging stem cell extract.

The Amazing Results
In order to test the theory that this unique plant extract would produce anti-aging effects, scientists at Mibelle Biochemistry first obtained human stem cells from the blood of an umbilical cord. Their first in-house study on cell viability showed that, at a concentration of only 0.1%, an extract of Uttwiler Spätlauber stem cells stimulated the proliferation of human stem cells by an astounding 80%!

In a second experiment, these scientists irradiated the umbilical cord blood stem cells with UV light. Nearly 50% of the stem cells cultured in growth medium alone died, but the cells grown in the culture containing the special apple extract showed only a small decrease in the number of living cells.

Another in vitro experiment conducted by the scientists involved fibroblast cells. These are the most common of all cells in the connective tissue of the skin. They manufacture the collagen, glycosaminoglycans, reticular and elastic fibers, and glycoproteins that make up the extracellular matrix (connective tissues providing support to cells). Fibroblasts not only help provide a structural framework for the skin, they also play a critical role in wound healing.

In their experiment, the scientists treated fibroblast cells with hydrogen peroxide for two hours until the cells began to show classic signs of aging. In scientific terms, this means that several genes essential for cell proliferation and growth were significantly down-regulated. However, after incubating these cells for 144 hours in a 2% Uttwiler Spätlauber extract, this down-regulation of genes was effectively neutralized, and in some cases, it was actually reversed! In addition, the scientists noted that the expression of an important antioxidant enzyme called heme oxygenase 1 was also stimulated.

Finally, the scientists conducted a human study to determine the anti-wrinkle effectiveness of a special cream containing a 2% Uttwiler Spätlauber extract along with lecithin liposomes. This patent-pending cream (called PhytoCellTec™ Malus Domestica) was applied twice daily to the crow’s feet area of 20 participants. Wrinkle depth was reduced by an average of 8% after just two weeks, and by 15% after four weeks—thus reducing the signs of aging!

**إنه يدبّر لك فى الغيب أموراً لو علمتها لبكيت فرحاً**
pearls-3's picture
by
بعد التخرج


thanks Surprised

Y.M's picture
Y.M

Very interesting ,,Thanks

actually I feel like I heard about this experiment before Rolling Eyes Rolling Eyes

mbs2380's picture
mbs2380
بعد التخرج


إن شاء الله بس يستخدموها لنضارة الوش و صفاؤه، ما تقلب تنفيخ و تغييب معالم ..
Cool Very Happy

Green Wave's picture
Green Wave

Quote:
إن شاء الله بس يستخدموها لنضارة الوش و صفاؤه، ما تقلب تنفيخ و تغييب معالم ..

تتذكر وقت كنا بدار الوبرا ,, تتذكر هداك الفصل ؟؟ Eye-wink Eye-wink , وقت انت غيرت مكانك

mbs2380's picture
mbs2380
بعد التخرج


هي مو وقت شفتوها لأحلام مستغانمي، حين حدّثتكم عن سرّ كتابتاها وفنجان القهوة؟ Rolling Eyes

pearls-3's picture
pearls-3
بعد التخرج


وبالعلامة كتبت: ما في حدا وجهه طبيعي... حتى الشباب!!!! Rolling Eyes

Quote:
هي مو وقت شفتوها لأحلام مستغانمي، حين حدّثتكم عن سرّ كتابتاها وفنجان القهوة؟

قصدك كاسة الشاي يلي انكبت Laughing out loud Eye-wink

ينذكر وما ينعاد بكل شي فيه Rolling Eyes Rolling Eyes Embarrased

pearls-5's picture
pearls-5
السنة السادسة


Embarrased

Crying or Very sad

Embarrased

Crying or Very sad

"الفضلة للفضيل" ... Laughing out loud Laughing out loud Laughing out loud Laughing out loud

pearls-3's picture
pearls-3
بعد التخرج


تماماً , وعلى فكرة مرة تانية شفناها ب"كراجات القابون" كانت ماشية هي وشرطي عميعمل بحث عن الديناصورات وعميلحقو وحدة مشان تقنع يلي بلم "القمامة" انو يجي عالساعة 7 بدل الساعة 8 .

Rolling Eyes

mbs2380's picture
mbs2380
بعد التخرج


على فكرة إذا مهتمبن كتير بالخلايا الجذعية، شفت إعلان بجريدة يمكن، مالي متذكر اسمها، عن إنه بدن موظف بيعرف بالخلايا الجذعية، ما بعرف شو طبيعة العمل بس أكيد ما حتخسروا شي قدموا و ممكن تستفيدو ، يعني بتطلعو عالفكرة بقرب أكتر.
بس نصيحة ما تقولوا دغري إنه انتو طلاب طب، لأن بعرف وحدة، أنا نصحتها ما تتصل، بس أبوها أصر انه تتصل، المهم من أول كلمة سألوها انت طالبة طب، دغري جاوبها ماشي منتنالك التوفيق، سلام.

عنجد بدي واحد يكمل بهالموضوع، بعرف واحد بلش بطريقه بس بعدين ترك Rolling Eyes Rolling Eyes
بقى إن شاء انتو تحققولي أملي ..

سلام

Green Wave's picture
Green Wave
ابق على تواصل مع حكيم!
Google+