توضح الصورة السابقة الآليات المحتملة لنشوء خلية ريدسترندبيرغ والدور المحتمل لـ EBV في نشوء هذه الخلية، والتي تفرز سيتوكينات مختلفة تحدد نمط الخلايا التي سوف تشارك بتشكيل لمفوما هودجكن
The Staging of Hodgkin Lymphoma:
1: one Lymph node involved
2: more than one lymph node group in one side of the diaphragm
3: Lymph nodes in both sides of diaphragm
4: Wide Spread
and every stage divided to A, B: B means there is constitutional symptoms like fever, weight loss, which worsens the prognosis
The best initial test: it's Excisional Lymph node Biopsy, DON"T answer Needle biopsy EVER
the next step after confirmation the diagnosis is staging the lymphoma by doing CT
the first two stages are treated by radiation, and 3-4 stages by Chemotherapy (ABVD)
Yah, logically, radiation is more reliable in more localized cancers than diffuse. In stage 1 and 2, radiation will be more reliable cuz we focus the treatment on specific area. This is not true in stage 3, 4.
I think, most doctors prefer radiation (if it's effective) over chemo, chemo has more systemic unwanted effects. True?
شكرا عمار
حسناً، EBV ليست مسؤولة عن كل حالات هودجكن، في أمريكا، أغلب الحالات ليس لها علاقة بـ EBV. مشكور على التوضيح.
صحيح
يعتبر فيروس إبشتان بار من الأسباب الهامة للمفوما هودجكن ولكنه ليس السبب الوحيد
يعتبر ابشتاين بار من الأسباب الهامة للمفوما بيركيت (اللمفوما الإفريقية)
The Staging of Hodgkin Lymphoma:
1: one Lymph node involved
2: more than one lymph node group in one side of the diaphragm
3: Lymph nodes in both sides of diaphragm
4: Wide Spread
and every stage divided to A, B: B means there is constitutional symptoms like fever, weight loss, which worsens the prognosis
The best initial test: it's Excisional Lymph node Biopsy, DON"T answer Needle biopsy EVER
the next step after confirmation the diagnosis is staging the lymphoma by doing CT
the first two stages are treated by radiation, and 3-4 stages by Chemotherapy (ABVD)
يعتبر ابشتاين بار من الأسباب الهامة للمفوما بيركيت (اللمفوما الإفريقية)
تماماً
لأنو كتير خطير معناتو
بعرف بس كانت إضافة
بس الـ
I think both stages need Chemo (ABVD), but duration of treatment differs. In first 2 stages: 2-4 weeks. Others: 6-8 weeks.
Reference: Medstudy 2007-2008
That's what I know, but I depend on Master the boards 2010
I think, most doctors prefer radiation (if it's effective) over chemo, chemo has more systemic unwanted effects. True?