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المعلومة

A 54-year-old obese woman has chronic gastoesophageal reflux.which of the following drugs are known to exacerbate her reflux esophagitis?

A. Chlorpropamide
B. Metoclopramide
C. Theophylline
D. Acetaminophen
E. Omeprazole

المرجع

NMS Medicine

by


theophylline
other drugs that may exacerbate GERD: b-blockers, calcium channel blockers (nifidipine) , anticholinergics

Ghufran's picture
Ghufran
بعد التخرج

Quote:
theophylline
other drugs that may exacerbate GERD: b-blockers, calcium channel blockers (nifidipine) , anticholinergics

AND NO

mbs2380's picture
mbs2380
بعد التخرج


Omeprazole is proton pump inhibitor drug, so it is used in treatment, and Metochlopramide is a gastrointestinal motility stimulant it is described as a treatment too, but is bronchodilator in asthma and used in bronchitis

klarias's picture
klarias

Gr8 !
Gufran,Mbs,Klarias. thans all

so, if she has a chronic asthma, what will you do? will you just stop Theophylline and let her die? or what?

DR-MAK


first it's important 2 remember that GERD may associate, cause or exacerbates Asthma. so management of GERD is of high importance in controlling her asthma symptoms
u should strictly control GERD in asthma pts including all measures (lifestyle, medical, or even surgical if needed)
secondly, theophylline is no longer a first-line drug in treating asthma
inhaled steroids r the first line drugs
there r many drugs 2 treat asthma according 2 the severity of the symptoms.
eventhough some drugs used in asthma may have theoretical side effects on the lower esopheageal sphincter, but that maybe absent or insignificant or maybe prominent sometimes like the pt above with theophylline......

Ghufran's picture
Ghufran
بعد التخرج

Quote:
Metochlopramide is a gastrointestinal motility stimulant it is described as a treatment too, but is bronchodilator in asthma and used in bronchitis

i think there,s a mistake here
Metochlopramide is anti-emetic, it's nt a broncholdialtor
maybe u mean another drug

Ghufran's picture
Ghufran
بعد التخرج


I can see that there is a miss word here it is Theophylline, so sentence should be written like this
but Theophylline is bronchodilator in asthma and used in bronchitis

sorry for this misunderstanding

klarias's picture
klarias
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