A 24-year-old patient who is known to be infected with HIV-1 presents with a 2-week history of intermittent bloody diarrhea, urgency, abdominal pain, and malaise. Stool culture for enteropathogenic organisms is negative, and analysis for ova and parasites is similarly unrevealing. The patient is taking no medication. The diarrheal symptoms do not respond to a course of ciprofloxacin. Colonoscopic examination reveals multiple areas of ulceration and mucosal erosion. Biopsy reveals the presence of cells containing a large, densely staining nucleus and abundant intracytoplasmic inclusions. The most appropriate therapy for this patient is
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