A proposed mechanism for the anemia of chronic disease (ACD) is shown here. In the presence of infection, inflammation, or malignancy, the macrophage is stimulated to produce Interleukin-6 (IL-6), which induces the production of hepcidin by the liver. Hepcidin, in turn, through its interaction with the iron export protein ferroportin, inhibits iron absorption from the gastrointestinal tract and decreases release of iron from macrophages. Both effects lead to the reduced plasma iron levels (hypoferremia) characteristic of ACD.
Sat, 2007-09-29 15:58