I need your advice


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My grandma in a 72 y old lady with long history of HTN and stable angina treaded with 50mg daily atenolol and sublingual NG when she feels chest pain. For the past two years her HTN has become increasingly difficult to control so her physician added daily 10mg of lisinopril.
Last year she had a hypertensive crisis and rushed to the ER where she was treated with IV medication (I wasn’t home and don’t know the details)
Two months ago, I bought a sphygmomanometer and start measuring her BP on routine basis and found that her systolic BP never goes under 170 with a diastolic BP ranging from 90 to 110 so I raised the dose of her lisinorpil to twice daily and replaced her Tenormin(atenolol 50mg) with normotic (atenolol 100mg + HCTZ 0.25mg) and her BP normalized for a while
Two weeks ago her BP was 180/90 so I added Amlodipine to her regimen with little success. Yesterday she woke up with conjunctival hemorrhage in her right eye and BP of 170/100, but she refused to breakfast when I brought the NG and CCB.
After breakfast she took her Normotic and Lisinopril, on 12.00 her Amlodipine and on Sahour another tablet of Normotic and Lisinopril each. So she is now on : 200mg atenolol, 20mg Lisinopril, 0.5 HCTZ and 5mg Amlodipine. The last BP reading was 130/85 which she never achieved in the last whole year but her pulse now is 55.
So what is the best management for her now? should I continue these high doses of anti-HTN cocktail? I won’t take her to any cardiologist in Deir-Alzoor cause they all sucks and I don’t think she can or would travel to damascus as she hate physicians and buses, and everytime she travels she gets dizziness and headache for a week.
I forgot to mention the she is obese and very sedentary, the daily five prayers are the only time she leaves her seat and her knees hurt when she walks cause she has some degree of OA.

So what would you do if you were in my shoes ?

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وَلاَ تَمْشِ فِي الأَرْضِ مَرَحًا إِنَّكَ لَن تَخْرِقَ الأَرْضَ وَلَن تَبْلُغَ الْجِبَالَ طُولاً


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صورة dr.tabban

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OH GOD
hypertension dilemma, I suggest the following:
first of all, life style modification is mandatory, she need to exercise and to loose weight by diet changes "i.e become vegetarian", I know you’ll say that she can’t, but there are some programs for people as sedentary as she is, I will try to look online for some exercises and will link you later.
Meanwhile, take renal function , liver function, EKG, later she may need ultrasound cardiograph to assess the cardiac function complications to such long term uncontrolled hypertension.
Keep on the regimen you are using now, even though she is on high doses of anti-hypertensive medications, their side effects are much easier than an ischemic attack “hypertrophic cardiomyopathy”, and way much easier than intra-cranial bleed or stroke.
Also, you need to take down a little of beta blocker “target heart rate is 55-60”, so she is bradycardiac… I believe 100 mg atenolol daily are sufficient, and to increase her dose of ACEI and CCB, because it’s safer as the highest dose is still far away which is 40mg/day. and the highest dose of amlodipin is 10mg/day, if you don't want to increase the CCB dose, i believe you can safely use nitroderm pathcs 10mg/day, it is safe and it can be helpful antill you've figured it out, long acting isosorbide dinitrate is also safe...

the msot important thing is, if she can't take her medications regularly, then she has to break her fasting and pay "KAFFARAH", Islam do not take blame for patients, they have the right to break their fasting if they need to.

this was a small, inexperienced, internal medicine resident opinion.

the strongest suggestion, and the safest one of all is, to go all the way to Damascus and discuss the case with a fine cardiologist.

best wishes الله يحميلك ياها ويخلليها فوق راسك.

___________

be the change you want to see in the world


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صورة Dr_Ayyad

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I wish I could help but your grandma is 4 times the age of my oldest patient. sorry, hope she gets well soon

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thanks dudes
according to uptodate there is not additional benefit of atenolol doses over 100mg daily
regarding lisinopril the maximum does is 40 mg daily and for amleodipine it is 10mg daily

for nitrate, I think there is no use of it in treating HTN ?!!!!

anyway I put her now on 100mg atenolol, 20mg lisinopril and 5mg amleodipine and her BP reading is in the area of 160/90
I can do nothing more

thanks again for your advice

___________

وَلاَ تَمْشِ فِي الأَرْضِ مَرَحًا إِنَّكَ لَن تَخْرِقَ الأَرْضَ وَلَن تَبْلُغَ الْجِبَالَ طُولاً


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صورة dr.tabban

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you're welcome.
about nitroderm patches "لصاقات نتروديرم أكيد شايف منها" 10mg/day, there main use is ischemic heart disease not hypertension, but the do reduce blood pressure, i asked you to use them untill you find a better way. 160/90 is still VERY high for a person with ischemic heart disease.

___________

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حكيم فعّال

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Thank you big time for your advice fellow, but you know what? she does not need the patches, she need a transorbital cerebroectomy instead of the patches
Actually I realized that a main cause of the huge gap btw the first world and the third one is the patients themselves

the cause of my grandma consistently elevated BP is that she secretly take some OTC medication for cough which contain cortisone, she would never have talk to me about it, but yesterday while I was semi asleep, I heard her talking with my mom about it and that she shall not tell me about it as she know I will through it away

thanks again for your support

___________

وَلاَ تَمْشِ فِي الأَرْضِ مَرَحًا إِنَّكَ لَن تَخْرِقَ الأَرْضَ وَلَن تَبْلُغَ الْجِبَالَ طُولاً