Persistent Nausea and Vomiting

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الوصف الكامل Background: 

A 66 yo CF came to the ED with nausea and vomiting for two months. She had been admitted to an OSH a week ago for nausea and vomiting and an EGD was negative. She vomited on average two to three times per day - typically a couple of hours after eating a meal. The emesis was yellow and watery.


Medications
Fosamax, Novolog, Lantus, Furosemide, Digitek 0.25mg daily,
Citalopram, Amiodarone, Diovan, Vytorin, Coumadin, Iron tablets, Aspirin

الشكوى الرئيسية CC: 

القصة المرضية HPI: 

الأجهزة الأخرى ROS: 

السوابق المرضية الشخصية PMH: 

CHF, DM Type II, Atrial Fibrillation, Cardiomyopathy, Anemia, Osteoporosis, Osteoarthritis, Sleep apnea

السوابق المرضية العائلية FMH: 

الوضع الصحي والاجتماعي SH: 

الفحص السريري Clinical Exam: 

VSS
Chest: CTA (B)
CVS: Clear S1S2
Abdomen: Soft, NT, ND, +BS
Extremities: no c/c/e
Neurologic: awake and alert, normal speech
Psychiatric: normal affect, conversant, appropriate

التشخيص التفريقي DD: 

الاستقصاءات Investigations: 

التدبير Managment: 

كتابة حرة وطرح موضوع النقاش!: 

What is the most likely diagnosis?

Anything else?

What tests would you order?



Few things you have to clarify
Is there any abdominal pain
Is there any wieght loss
How about bowel movements
How long did she had diabetus for?
Any new medications or change in doses
Any heatburn or reflux sensations
Any moring headache
Does she bring up old undigested food

THe differential diagnosis of Nausea and vomiting is very wide (I think it is the most chanelling GI symptom) and careful detailed history is the key for diagnosis most of the time. I frequently see paople jumping to EGD (endoscopy ) to try to find the cause which is helpful on only 15% of the time.In 85% there is something that EGD is not going to help you with.

صورة ABIM


اقتباس:
Few things you have to clarify
Is there any abdominal pain
Is there any wieght loss
How about bowel movements
How long did she had diabetus for?
Any new medications or change in doses
Any heatburn or reflux sensations
Any moring headache
Does she bring up old undigested food

no abdominal pain
no weight loss
bowl movements were auscultated ,nothing abnormal
diabetes was diagnosed and monitored since she was 50.
she also complains that she got bored of these huge amounts of drugs she should take .
no heart burn ,no reflux sensation ,neither morning headaches.

صورة Green Wave


I really don't know,but do these medication cause such problem???

صورة mbs2380


man she is taking basicaly all kinds of chronic diseases medications, now i'm suspecting on of two things

either a GI upset due one of these 100 drugs she's taking, or it may be gastroparesis.
i was about to ask a question but i think ABIM has answered it for me, why EGD? why not an ultrasound first !

صورة ablackside


ok ,let's think about the main complaint:
dr.ABIM asked about the diabetes of the pt,maybe he was thinking about Diabetic gastroparesis,idon't no but anyways in more detailed examination the pt didn't reveal any other gastroenterologic symptoms ..
.........
let's think about sth else..
اقتباس:
either a GI upset due one of these 100 drugs she's taking, or it may be gastroparesis.

more investigations are available ..
اقتباس:

why EGD? why not an ultrasound first !

i think that dr.ABIM is the best to answer u ..with all respect

.............
mbs ..waiting HOUSE effectsVery Happy

صورة Green Wave


When you order a test you always ask yourself what are you looking for. SO you asked about US of the abdomen. What is the likelihood that US can show you a diagnosis that explains the vomting in the abscess of other GI symptoms (esp pain) ? If you can answewr this you will know why US is not a good test to order in this senario. But I see your point ablackside . Your thinking is based on doing less invasive testing before which is a good idea but the more important concept is to do the test that is more likely to yeild the diagnosis and not waste money .

صورة ABIM


today the pt has rang me up telling me that Hakeem Medical Mall didn't solve her vomiting condition..and she's forced to leave it cause she's still suffering the same nausea since she came this mall.
i told her to calm down and be patient coz her nausea is about to be worked out ..
i think our doctors will come tonight and reorganize your remedies..so don,t worry ..

صورة Green Wave


اقتباس:
could it be digoxin toxicity???

صورة mbs2380


could it be digoxin toxicity???
well,we will see...
after your suspect mbs about Digoxin intoxication ,we order the pt many tests :
CBC
CMP
Digoxin level
KUB, CXR
UA
EKG
i think that digo level and the EKG is enough ,but anyway we will check other things ,u know how chronic she is..
Later.........,
ECG showed a LBBB (not new, compared to previous EKGs) and first degree AVB, HR 64 bpm.

Laboratory results were unremarkable. Digoxin level was pending.
........
so you're right mbs ..
_______________________________________
what's the next step?

صورة Green Wave


I think this is will be the last time i transfer a pt to this Mall..my pt was ignored for many times and now after ur declaration of approaching a diagnosis for the pt ..u didn't even touch her..Mad
please doctors my pt's Digoxin level came back as 5.0 ng/mL. Repeated levels were 5.2 and 5.6 respectively.

The patient became bradycardic ...Pleeeeeease Do somethingggg...Crying or Very sad Crying or Very sad Crying or Very sad

صورة Green Wave


first we have to stop givving her the digoxin
then we give her Digibind
and I don't thin that we have to trat her first degree avb

صورة mbs2380


اقتباس:
then we give her Digibind

what do u mean bu Digibind??
if you mean " digoxin-specific Fab fragments ",we can give the pt what do u want .But if not,u should explain more Dr.
....................
Quizzes :
1. what the most important electrolyte we should monitor while giving the Digo.?
2.what are The indications for administration of digoxin-specific Fab fragments?

صورة Green Wave


digoxin-specific Fab fragments "=digibind

صورة mbs2380


Quizzes :
1. what the most important electrolyte we should monitor while giving the Digo.?
2.what are The indications for administration of digoxin-specific Fab fragments?

صورة Green Wave


اقتباس:
1. what the most important electrolyte we should monitor while giving the Digo.?

it is K+

اقتباس:
2.what are The indications for administration of digoxin-specific Fab fragments?

they are:

(1) ingestion of massive quantities of digitalis (children 4 mg or 0.1 mg/kg, adults 10 mg),
(2) hyperkalemia (>5 mEq/L),
(3) digoxin-induced ventricular dysrhythmias or high-grade AV block,
(4) rapidly progressive signs and symptoms of toxicity, (5) cardiac arrest or cardiogenic shock in a patient with suspected digoxin toxicity, and
(6) postdistribution serum digoxin levels greater than 5 ng/mL.



by the way :

old people are at high risk of digoxin toxicity, so : use lower doses.

the reference : OHCM



Thank you A.M you're right...
...........................................
now at the end ,just because it came to my mind,i hope u answer me:
WPW+Digoxin
What does it reveal to u?
.............
WPW :Wolf Parkinson White

صورة Green Wave