أسئلة امتحانية بالتشريح المرضي , صورة و تشخيص (3)

It's C

Fatty Change refers to any abnormal accomulation of TRIGLYCERIDES within PARENCHYMAL cells
Fatty change is most often seen in the LIVER
((ROBBINS BASIC PATHOLOGY))

Alcoholism leads to fat accumulation in the liver, hyperlipidemia,and ultimately cirrhosis.
Oxidation of Ethanol (to Acetaldehyde) by alcohol dehydrogenase leads to excess production of NADH.
Acetaldehyde is oxidized by aldehyde dehydrogenase (more NADH), producing acetate.
The NADH generated competes with reducing equivalents from other substrates, including fatty acids, for the respiratory chain, inhibiting their oxidation, and decreasing activity of the citric acid cycle.
The net effect of inhibiting fatty acid oxidation is to cause increased esterification of fatty acids in triacylglycerol, resulting in the fatty liver.
((Harper’s Illustrated Biochemistry))

THANX TECHNO